Folic acid supplementation increases the risk of prostate cancer

A study by University of South Carolina researchers shows that men enrolled in this study for 10 years received a daily supplement of 1 mg of folic acid and then developed a risk almost 3 times more prostate cancer than the same study subjects who received placebo, informs Science Daily.

These results are in fact a second analysis of a survey held between 1994 - 2006, entitled AFPP (Aspirin / Folate Polyp Prevention Study), whose purpose was the impact of aspirin use and folic acid in prevention of colon polyps and patients with risk malignizare increased them. Rezultate studiului AFPP au fost ca aspirina reduce riscul aparitiei si malignizarii polipilor in timp ce acidul folic a crescut acest risc, nefacandu-se insa nici o referire la legatura dintre acidul folic si cancerul de prostata. Results of the study were AFPP that aspirin reduces the risk of polyps and malignizarii while folic acid increased the risk, but nefacandu is no reference to the link between folic acid and prostate cancer.

In its second review of the same study we aimed to prostate cancer in 643 male subjects were randomized into two groups, first received the supplement of 1mg folic acid / day and the other placebo.

The resulting data showed that in the group treated with 1 mg of folic acid daily for 10 years, the risk of illness from prostate cancer was 9.7% versus 3.3%, as was recorded in individuals taking placebo .

On the biochemical, folic acid is a water-soluble vitamin B group, very important line erythrocyte maturation (folic acid deficiencies leading to anemia), in the processes of DNA replication and involved in cell division. Aceasta vitamina este recunoscuta pentru actiunile sale in prevenirea defectelor de tub neural la fat, in cazul administrarii mamei inainte si in timpul sarcinii. This vitamin is known for its actions in preventing neural tube defects in fetus when given the mother before and during pregnancy. Sursele naturale de acid folic sunt legumele si fructele proaspete, leguminoase, cereale integrale. Natural sources of folate are vegetables and fresh fruit, legumes, whole grains.

Although there is no one conclusive in this bibliography, there are previous studies, which come in contrast with results researchers at the University of South Carolina, which have supported the hypothesis that folic acid in food (not produce synthetic supplementation) would a certain extent reduce the risk of prostate cancer, and in general the risk of malignant events. Certitudinea acestor rezultate este discutabila deoarece o dieta cuprinzand alimente bogate in acid folic aduce un aport important de alti elementi cu antioxidant si efect anticancerigen cum ar fi vitaminele A, C, E , minerale precum Zinc, Magneziu. The certainty of these results is questionable because a diet including foods rich in folic acid make an important contribution of other components with antioxidant and anticancer effects such as vitamins A, C, E, minerals such as zinc, manganese.

In terms of pharmacodynamics, the plasma bioavailability of synthetic folic acid supplements nature is much higher than that obtained from usual food sources, and therefore they can forward the hypothesis that very important is folic acid concentration in blood plasma of an individual It distinguishing between beneficial effects of the substance and its toxicity.
Autorii studiului au concluzionat ca dozele zilnice alimentare de acid folic (DZR = 300 micrograme) sunt benefice, manifestand efecte anticancerigene, in timp ce depasirea DZR , asa cum a fost in cazul de fata de peste 3 ori normalul, a dus la o crestere proportionala a riscului de imbolnavire a barbatilor de cancer de prostata. The study authors concluded that daily doses of folic acid food (RDA = 300 micrograms) are beneficial, showing anticancer effects while overcoming RDA, as it was in this case more than 3 times normal, resulting in a proportional increase disease risk of men for prostate cancer.